This free software:
http://killbox.net/
can be invaluable in known malware situations. Sometimes the Task Manager process list shows suspicious .EXE’s running; a Google search may (or may not) confirm it as spyware. If you are very sure, Killbox will sometimes terminate the running process for you, but even if it can’t do that, it will tell the system to delete the .EXE at next reboot. This can be a very good approach when antimalware scanners fail.